Abstract
Ignota Labs were formed in 2022 by Jordan Lane, Dr Layla Hosseini-Gerami and Sam Windsor as they recognised a gap in the drug discovery market, where more than half of all clinical trials are failing due to safety issues. With their collective experience, three co-founders’ backgrounds Ignota Labs was born to tackle this problem through AI and Machine Learning. The founding team of two PhDs and two MBAs from top institutions including Cambridge University and INSEAD business school, includes a seasoned drug discovery expert, a machine learning researcher and an experienced healthcare strategy specialist.
Our programme manager, Emily Vipond from the Royal Society of Chemistry (RSC), caught up with Ignota Labs’ Layla Hosseini-Gerami (Chief Data Science Officer) to find out what they have been up to since winning the 2024 Emerging Technologies Competition in the Health category.
Who are Ignota Labs?
Fifty-six percent of drug discovery projects reaching a phase one clinical trial will fail due to unforeseen safety problems, such as liver toxicity. This represents a huge loss of money, time and resources that have gone into a given trial. Ignota Labs are using AI and machine learning to tackle this issue.
When the company started out in 2022, their business model was focused on identifying drug failures early in the drug discovery process. They started by doing proactive safety screening, but they quickly realised that they needed to think of an alternative business model to really capture the value within this space. There is a lot of competition “upstream” in the drug discovery process, but Ignota Labs are uniquely positioned to offer value when drugs are transitioning to the clinic, so that more drugs actually make it to the patients who need them.
Ignota Labs have now geared their business and technology to focus on understanding why things go wrong when they do. Layla says, ‘So once the drug has already gone into an animal in a preclinical study or into a human in a phase one study, often at that point, some kind of toxicity issue will be borne out that was completely unexpected. So instead of just throwing these drugs to the side, and wasting all that time and money, we analyse these drugs and understand what went wrong, understand if that's a problem that we can solve.’ Layla goes on to say, ‘And then if we believe that it's a solvable safety issue, we in-licence the drug to turn it around. By this I mean we fix the toxicity issues and then after putting it back through clinical trials up to phase one, we then sell the drug. [This means] a drug that would have been sitting on a shelf gathering dust, becomes an option for patients who are waiting for a treatment for that disease. We're coming in and giving hope to these patients by reviving these drug projects that would otherwise just be discarded.’
What have you been up to since winning the competition?
Since winning the competition Ignota Labs have been extremely busy. Their biggest milestone Layla says, ‘Is closing our seed funding round, we spent a lot of our time [on this] last year and being able to say that we won the Emerging Technologies Competition gave us validation. That what we're doing is good, a panel of experts has looked at what we've done and has said that it's innovative. It’s a stamp of approval when you speak to investors, especially ones that aren't specialists in chemistry or drug discovery or machine learning necessarily, to know that someone who is an expert has looked and has said that this is something that's award-winning.’
As well as raising investment, Ignota Labs acquired their first drug asset where they solved a safety issue that was unsolvable by the biotech that previously owned it. Ignota Labs will now take that drug through preclinical and phase one trials before they commercialise it.
Layla mentions, ‘We won Sanofi’s iDEA-Tech Award, which is a global competition aimed at accelerating breakthroughs in pharmaceutical R&D using AI and data-driven solutions. We will be working on a pilot with Sanofi to better understand the underlying mechanisms that cause organ toxicity.’
To conclude Layla says, ‘I also received Innovate UK’s Women in Innovation award. This will support a project to expand our platform to address the significant gap in drug safety understanding in diverse populations. In partnership with Genomics England and Cytochroma, we will look at how patients’ genomics profiles affect liver toxicity risks.’
Looking ahead to 2025 Layla says, ‘We are all kind of raring to go and just expand the company operations. We are focusing on acquiring more drug assets to add to our portfolio; we’re currently assessing the potential of our next asset.’ Layla continues, ‘We will start developing the drug asset that we already have in-house. We still must do some very pivotal efficacy experiments, which will then enable us to go and raise more funds to further develop the drug and actually put it into these expensive trials.’
Layla says, ‘Continuing to improve the technology, and with the Innovate UK grant, looking at genomics data that will hopefully be a step into the world of doing more personalised assessments of toxicity, so really understanding which patients will show toxicity and which ones won’t and informing clinical trials and understanding better when things have gone wrong.’
Laylas concludes, ‘In the next 5 years, I really see us making a name for ourselves in terms of being the company that can turn around failed drugs. We've had one example now, but one example is never enough. So, over the next five years, just really building that reputation for us as being that company.’
What made you apply to the Emerging Technologies Competition?
‘So, for us it was really about that validation piece,’ Layla says. ‘It’s a signal from the industry that what we're doing is good and it's the right thing to be doing. Being a very early-stage company, you don't have a lot of money to go out and do case studies, it’s really nice to have that validation from institutions like the RSC. It gives us that badge of honour that can help us to reach the next level.’
Layla continues, ‘We had applied the year before and had been unsuccessful. The business has moved on a lot since our last entry, so going back and trying again and saying, “we've taken all [the judges] feedback on board, we're here and we're ready to try again,” was also another motivating factor.’
What did you like best about taking part in the Emerging Technologies Competition?
‘The pitch day is just an absolutely amazing day because it's a full day of just hearing about all these very smart, very talented people that have come up with something amazing in the world of chemistry. Being very inspired by the very strong competition in the room.’
What advice would you give to anyone looking to apply to the 2024 Emerging Technologies Competition?
Layla says, ‘Firstly to just go for it! Even if you think you might not win or you might not get to the final, all the feedback that you receive is very, very useful and very helpful and worth the time of applying even just for that.’ Layla continues, ‘Then I would say that when you write your application, just really keep in mind the audience and what you're trying to convey, because a lot of the time these innovations can be very technical, very specific. And I think it's important to keep the big picture in mind. When you're writing your application, really focus on the: what or what you're doing, how it can impact the world in a positive way, even if you're super early.’